In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+
If it is high, it might be worth seeing what your methylmalonic acid (MMA) is doing
They are injected directly into your muscles by a doctor and are very effective in increasing B12 levels in your blood and preventing or reversing B12 deficiency
A normal level is 400 pg/mL or higher
If you are considering B12 for energy, tiredness or a diagnosed deficiency, our B12 injections page has the detail, and you can book a free consultation to talk it through first
For most drugs, this doesnt matter, but if you take medications where precise timing is important (such as some antibiotics that need an empty stomach, or thyroid hormone replacement), mention this to your prescriber or pharmacist