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The sensation of feeling cold appears to be an indirect consequence of the metabolic and body composition changes induced by the medication, rather than a direct drug effect on temperature regulation centres in the hypothalamus

A 0.125mg dose is only 3.75 units at 3.33mg/mL concentration, a volume that pushes the limits of syringe accuracy

10.1016/j.jacc.2013.02.092 13

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Agents like Setmelanotide or GLP-1 RAs may be integrated alongside nutritional, behavioral, and endocrine support to optimize clinical outcomes (Figs