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Retatrutide may have an edge for weight loss because it targets three hormone receptors instead of two

This step-up process matters because gastrointestinal side effects such as nausea, constipation, reflux, diarrhea, or reduced appetite can be more noticeable when the dose increases too quickly

The idea is not new, as already Otto Warburg et al

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The reduction in metabolic rate that occurs during prolonged caloric deficit, resulting in fewer calories burned at rest than predicted for a given body weight