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DATS protected cardiac cells in vitro and in experimental diabetic rats from high glucose-induced oxidative stress and apoptosis by inducing PI3K/Akt-dependent Nrf2 antioxidant signaling (23)

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[24] [25] Adjunctive therapies may include intermittent pneumatic compression devices for home use, weight management programmes (as discussed previously), and psychological support to address the emotional impact of living with a chronic, visible condition

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The principle is the same as exposure therapy, gradually teaching your nervous system that the stimulus is not threatening

Use that flexibility to your advantage instead of treating it like a rigid protocol that requires optimization