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nucleatum is enriched in individuals with early-stage CRC ( Clostridium butyicum , a butyrate producer, and Lactobacillus and Streptococcus thermophilus , which produce lactate

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FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci

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