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The results were measured with 3D skin surface imaging, not subjective assessment: GHK-Cu reduced wrinkle volume by 55.8% compared to a control serum

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Furthermore, the paper delves into the genetic basis of these effects, revealing that GHK-Cu modulates the expression of numerous antioxidant genes

When the gene has either of these two variants, the resulting MTHFR enzyme is slightly less active, which can lead to lower levels of folate, and higher levels of homocysteine