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These studies focus strictly on molecular resilience and signaling integration within controlled research environments, rather than any physiological recovery or therapeutic outcomes

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360 Additionally, studies have shown that the expression of PGC-1-responsive genes is downregulated in the brains of PD patients, possibly due to hypermethylation of PGC-1 transcriptional elements, leading to bioenergetic dysregulation

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This finding strongly encourages further investigation into the potential of agents that enhance GLP-1R signaling as treatments for glaucoma (79)