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Although 6-phosphoglucono--lactone is hydrolytically unstable and can undergo spontaneous (nonenzymatic) ring-opening at a significant rate, this hydrolysis reaction is greatly accelerated in the cell by the enzyme 6-phosphogluconolactonase (EC 3.1.1.31)

The combined protocols cost-per-outcome ratio is superior because it addresses the rate-limiting variables that prevent either compound from reaching maximum efficacy alone

49 BCAA in cancer Changes in circulating levels of BCAAs have been reported in cancer patients

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