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First and foremost, GLP-1 mediated signaling in the brain has a well-established neuroprotective effect, which has been repeatedly proven to enhance memory and cognitive functions, improve neurogenesis and synaptic functions, as well as restore balance in neurotransmission, i.e

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Next, the following four target prediction databases were selected to retrieve targets for the GLP-1RAs: (1) The Binding Database ( a public and web-accessible database containing 2,096,653 binding data points for 8,185 proteins and over 920,703 drug-like molecules (Gilson et al., 2016)

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