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Pieter Cohen, Associate Professor of Medicine at Harvard Medical School and a researcher on dietary supplement safety, has noted: "When public figures attribute results to willpower alone while potentially using prescription drugs, they set unrealistic benchmarks that can cause real psychological harm to people who cannot achieve the same outcomes through lifestyle changes." The AMA's Position The American Medical Association adopted policy in 2023 urging transparency in celebrity health endorsements, specifically calling on public figures to disclose when health outcomes are achieved with medical assistance 10

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At the same time, carbohydrates have a relatively weaker stimulatory effect (30)

Data from the STEP [52] and SUSTAIN [53, 54] trials consistently demonstrate that the substantial weight loss achieved with semaglutide at doses of 0.5 mg, 1.0 mg, and 2.4 mg is largely independent of these symptoms, with less than 1% of the total weight loss benefit attributable to GI AEs