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Methylglyoxal activates NF-kappaB nuclear translocation and induces COX-2 expression via a p38-dependent pathway in synovial cells

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Non-enzymatic antioxidants like glutathione, uric acid, and bilirubin also play a role

Allergic Reactions and Gastrointestinal Issues If you experience any allergic reactions or gastrointestinal issues, such as cramping, bloating, or diarrhea when taking glutathione supplements, its recommended to discontinue use and consult your healthcare provider