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Timothy Garvey, MD Professor of Medicine University of Alabama at Birmingham, Birmingham, Alabama, USA Director, UAB Diabetes Research Center Dr

Where It Acts The primary target cells are dermal fibroblasts (the cells responsible for producing collagen, elastin, and the extracellular matrix proteins that give skin its mechanical structure) and basal keratinocytes (the proliferating cell population at the bottom of the epidermis)

Consider both only when the research objective clearly benefits from addressing both superficial tissue remodeling and deeper structural recovery pathways

Step-by-Step Reconstitution Protocol Step 1: Equilibrate the vial to room temperature Remove the vial from the freezer (if stored frozen) and allow it to reach room temperature before opening

Sections were examined under bright fields and polarized illumination