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1,2,6 Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense

This captures the proven benefits of higher doses during active weight loss while using microdosing principles for the long-term phase where the goal shifts from losing weight to not regaining it

Diabetes Care 25 (12), 21652171

For best absorption: Take it first thing in the morning Use a small amount of water (no more than 4 oz) Wait at least 30 minutes before eating, drinking, or taking other medications Following these instructions closely helps the medication work effectively

(August 2010)