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Pyruvate, -ketoglutarate, glutamate, and aspartate all stayed constant between the two groups (Figure 1)

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Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruchs membrane

In simple words, an event-like hemolysis stresses the bone marrow to compensate for the loss of RBCs and in an attempt to do so, there is a predilection for -chain or HbF synthesis because of its higher oxygen affinity and increased oxygen delivery to tissues in hypoxic conditions (Feng et al