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Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69
10.1007/s10930-022-10074-5 13 HepsomaliP.GroegerJ
What dose was used in trials
On the other hand, IGF-1 acts as an insulin sensitizer that does not exert any direct effect on lipolysis or lipogenesis
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Efficacy and safety of LX9211 for relief of diabetic peripheral neuropathic pain (RELIEF-DPN 1): results of a double-blind, randomized, placebo-controlled, proof-of-concept study
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