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PubMed, EMBASE and MEDLINE scientific databases were searched individually and/or in combination using the following keywords: (Apoptosis OR Autophagic cell death OR Necroptosis OR Pyroptosis OR Ferroptosis) AND (Natural products OR Plant metabolites OR Flavonoid OR Bioactivity OR Structure-activity relationship) AND (granulosa cells OR oocytes OR diminished ovarian reserve OR premature ovarian insufficiency OR premature ovarian failure OR ovarian aging OR poor ovarian response OR poor responders undergoing IVF OR poor response to ovarian stimulation)

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Patients drink a calibrated solution of lactulose (large molecule, should not pass through an intact gut lining) and mannitol (small molecule, normally absorbed)

Biochem Soc Trans 2007

See our complete guide to the Epithalon protocol at Perfect B: the 10-day cycle, reconstitution, and what patients can expect from each annual reset

Use both for the best outcome