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The Medicare GLP-1 Bridge offers an opportunity to begin evaluating those competing projections against real-world experience
It means millions of people taking these drugs long-term
Semaglutide held 51.35% of prescriptions in 2025, making it the dominant agent
But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create
Despite their remarkable clinical success, several real-world barriers have constrained broader adoption
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