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The observational association between low B12 and cardiovascular disease risk is clearer than the causal effect of supplementation on outcomes
Maintains stability for extended research use
Plasma concentrations decline with age - from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60
This modification is thought to improve stability and cellular uptake, with the acetyl group being removed once inside cells to release active glutathione
This is the beginning of a regulatory pathway, not the end
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