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IGF-1 LR3 is engineered with an N-terminal extension and Arg3 substitution that reduces IGFBP-3 binding, extending its effective activity substantially longer in preclinical models
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Jin, X.-W., Liu, B.-K., Zhang, X., Zhao, Z.-H
The most common version, CJC-1295 with DAC (Drug Affinity Complex) , binds to albumin in the bloodstream and remains active for several days
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