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The primary evidence comes from the 2017 Cell paper using aged and chemotherapy-treated mice, and subsequent mechanistic studies
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Avoid blowing your nose for 15-20 minutes after administration
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PLoS ONE 8 , e58764 (2013)
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Other growth factors such as bone morphogenetic proteins (BMPs) have received FDA approval for specific indications and may represent more appropriate therapeutic choices for conditions where approved therapies are available and indicated
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