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Triple-negative breast cancer (TNBC) has a poor response to endocrine and anti-HER2 therapies, and chemotherapy is the primary treatment in addition to surgical resection
Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions
Since NPW receptors are widely expressed in the peripheral tissues that include blood vessels (Chottova Dvorakova 2018), NPW may have a regulatory function in the maintenance of gut microcirculation without affecting prostaglandins in the acetic acid-induced gastric ulcer, which may contribute to the ameliorative effect of NPW treatment in chronic gastric ulcer
In starvation or low-energy states, SIRT1 activation is regulated by AMPK, which increases lifespan by increasing NAD + levels and activating SIRT1 (Zullo et al., 2018)
Sublingual glutathione - taken under the tongue
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