Weighted Median method also showed appendicitis did not increase risk of CRC (P were all greater than 0.05)
If there has been long-standing damage, this triggering might overwhelm the system, temporarily worsening symptoms
This blog provides framing and overview
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The FDA approved once-daily oral semaglutide (Wegovy) at 25 mg on 22 December 2025, making it the first oral GLP-1 approved specifically for chronic weight management in the US
These drugs, such as Novo and partner Marcadias MAR423, Hanmis HM1521, Sanofis SAR441255, and Eli Lillys retatrutide, are currently in early- to mid-stage trials