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These authors concluded that there is an increase in eryptosis levels with progressive residual diuresis and rGFR loss, probably due to decreased uremic toxins [268]

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Combination therapies were shown to have stronger benefits regarding most of the measured parameters [including abnormalities in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations, markers of systemic inflammation (clear reductions of IL-1 levels), liver inflammation, hepatocellular oxidative stress, hepatic fibrosis and hepatocyte apoptosis] vs