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In this review, we discuss the mechanism of action of GLP-1 RAs, focusing on their proposed cardiometabolic impact and the key clinical trials that have demonstrated improvement in cardiovascular outcomes
6- 11%
PMID: 39265666 | doi:10.1016/j.arthro.2024.09.005 Lee E et al
Commercial plans, Medicare Advantage, and Medicaid products each maintain separate formulary guidelines for semaglutide and tirzepatide
The SUMMIT trial took this further with tirzepatide, showing a 38% reduction in the composite of cardiovascular death or worsening heart failure (HR 0.62) in patients with HFpEF and obesity, along with a clinically meaningful 6.9-point improvement in KCCQ scores
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