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Schedule an appointment if you experience: Sudden or significant decrease in sexual desire that affects your quality of life or relationships New-onset erectile dysfunction or difficulty with arousal Painful intercourse or other physical symptoms during sexual activity Concerning changes in sexual function accompanied by other symptoms such as mood changes, fatigue, or hormonal symptoms New or worsening depression or suicidal thoughts (Zepbound carries a warning for suicidal ideation) Severe, persistent abdominal pain (with or without vomiting), which could indicate pancreatitis or gallbladder disease requiring urgent evaluation Your physician can conduct a thorough assessment to identify potential underlying causes

DPP4 Substrates: SDF-1- and BNP-Dependent Effects of DPP4 Inhibitors But beside GLP-1, there are further substrates of DPP4, which might play a role in the favorable cardiovascular effects of DPP4 inhibitors

In fact, cardiovascular disease is the leading cause of death in MASLD patients 3,6

For advice, contact your pharmacist or call the manufacturer at 1-800-727-6500