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[13] In a newly diagnosed vitamin B 12 -deficient patient, normally defined as when serum levels are less than 200 pg/ml, daily IM injections of hydroxocobalamin up to 1,000 g (1 mg) per day are given to replenish the body's depleted cobalamin stores

Its high proline content (five of fifteen residues) is widely cited as the structural basis for its unusual proteolytic stability

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doi: 10.1007/s00011-007-7141-z 152 SvetlovSIBartonJMOlsonMS

They must be reconstituted before they can be used for research or therapeutic applications