Industry-wide, big pharma and biotech have in recent years announced major AI or supercomputing initiatives
Skipping titration steps increases the risk of severe nausea, vomiting, diarrhea, and constipation
For reference on what standard titration looks like, the starting dose of tirzepatide guide covers what patients typically experience in the early weeks
doi: 10.3389/fphar.2022.836849 27 ManciniSJBoydDKatwanOJStrembitskaAAlmabroukTAKennedySet al
Nielsen SE, Persson F, Frandsen E et al (2012) Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: a randomized placebo-controlled crossover study
A prime candidate for Riegles first pilot study, he was also a skeptic