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1 In adults with obesity, along with diet and exercise, A well-studied safety profile for adults with obesity: Pooled safety data from 2 weight-management clinical trials evaluating Wegovy HD 7.2 mg 1 Wegovy HD (semaglutide) injection 7.2 mg had a safety profile consistent with Wegovy 2.4 mg 1,3 5% of patients with Wegovy HD 7.2 mg pen, 5% of patients with Wegovy 2.4 mg pen, and 2% of patients with placebo permanently discontinued as a result of adverse reactions 1 The most common adverse reactions leading to discontinuation were gastrointestinal disorders: 3% of patients with Wegovy HD 7.2 mg pen, 3% of patients with Wegovy 2.4 mg pen, and 0.3% of patients with placebo 1 Includes allodynia, burning sensation, dysesthesia, hyperesthesia, hyperpathia, pain of skin, paresthesia, sensitive skin, skin burning sensation, skin discomfort, and skin sensitization

Food and Drug Administration (FDA) have approved semaglutide for certain medical conditions

Individual responses to GLP-1 therapy are influenced by baseline health status, concurrent medications, dietary habits, and lifestyle factors

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In contrast, the beneficial effects of SGLT2 inhibitors on albuminuria and eGFR decline in DKD were demonstrated by EMPA-REG OUTCOME (Wanner et al., 2016), CANagliflozin cardioVascular Assessment Study (CANVAS) ( Statements Author contributions DK and YT wrote and revised the manuscript

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