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Smith SR, Aronne LJ, Burns CM, Kesty NC, Halseth AE, Weyer C
I was running on fumes
Administration of CCK, in humans and animals, inhibits food intake by reducing meal size and its duration.17,18 Recent work suggests that CCK-A receptors expressed by vagal afferent neurons are an important target for CCK in producing sensations of satiety, as well as inhibiting gastric emptying and stimulating pancreatic digestive enzyme secretion.19 In animals it is thought that the reduction in food intake may be mediated by a paracrine/neurocrine effect since high concentrations of CCK occur only locally to the site of release.20 Thus, locally released CCK may increase vagal tone, without a significant increase in plasma CCK level
The changes are primarily linked to weight loss rather than a direct effect of the medication itself
10.1055/s-2003-44554 101 MeiH.XiangY.MeiH.FangB.WangQ.CaoD.et al (2018)
Step 3: Administer the dose on the new day
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