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Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% from baseline at 48 weeks a figure that, whilst encouraging, should be interpreted with caution as cross-trial comparisons with approved agents are not methodologically robust in the absence of head-to-head data
CAG:100, Faecalibacterium prausnitzii 7, F
Muscle and heart disease: including muscle weakness, cardiomyopathy (myocardial hypertrophy or dilation), and arrhythmias.Nervous system effects: may manifest as brain damage, seizures, intellectual disability, ataxia, etc
In parallel, redox-sensitive transcription factors such as NF-B are activated, upregulating adhesion molecules, chemokines, and pro-inflammatory cytokines (7)
