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Additionally, compared to glimepiride, a commonly used sulfonylurea, exenatide was able to significantly reduce cardiovascular risk factors such as body mass index, blood pressure, and high-density lipoprotein (HDL)
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Extensive phase 3 trials on semaglutide use in T2D patients showed significant reductions in blood HbA1c and fasting plasma glucose (FPG) levels within just 12 weeks of once-weekly, subcutaneously [5]
Heavier individuals may require slightly higher doses, but starting conservatively remains appropriate regardless of weight