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FIGURE 1 Platinum accumulation in dorsal root ganglia The accumulation level of Pt drugs in DRG is 1020 times higher than that in other nerve cells, which could be attributed to the high expression of Pt-related transporters (e.g., Ctr1/2, OCTs) in DRG (Trecarichi and Flatters, 2019)
IV therapy can also be effective in managing acute conditions like migraines, providing rapid relief from symptoms
227 Histone acetylation increases the accessibility and gene expression of various transcription factors by reducing the positive charge and histone affinity for DNA
(2) It may also interact with alternative receptors such as the 3-adrenergic receptor
Biochemically, once ferroptosis is activated, it cannot be suppressed by apoptosis, necrosis, or autophagy inhibitors but can be hidden by iron chelators such as deferoxamine (DFO) or antioxidants such as Trolox and fer-1
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