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It has also been shown to induce apoptosis99 and exert antiangiogenic effects.100 After the first reported case of imiquimod-treated LM was published in 2000,101 by 2006 there were descriptions of 68 cases treated in this way according to a review of 15 reports in the English-language literaure.102 The authors of the review concluded that, because of the risk of leaving invasive or residual disease, without controlled evidence and prolonged follow up, the use of imiquimod for LM must still be considered experimental.102 The literature now contains reports of the use of imiquimod in 234 patients with LM, all from uncontrolled studies

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