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Mini Rev Med Chem
Evidence based on recent studies Initially, cases of intestinal obstruction associated with GLP-1 RAs were reported by the European Medicines Agency (EMA) in 2013 [9], and this safety signal is currently being monitored by the United States (US) FDA
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10.1056/NEJMoa1501352 127
pH-sensitive micelles loaded with epirubicin specifically localize to lysosomes and induce dose-dependent alkalization, which impairs autophagic flux and sensitizes cancer cells to the drugs cytotoxic effects [43]
Blok PH, Manni JJ, van den Brock P, van Haelst UJ, Slooff JL
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