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[1] Additionally, GLP-1 receptor agonists including semaglutide are associated with an increased risk of gallbladder disease, which can present with right upper quadrant pain, fever, or jaundice

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Safety and Tolerability: Where They Diverge Both compounds share the tolerability profile typical of appetite-suppressing metabolic peptides, but retatrutide carries additional signals that trace directly to its glucagon arm

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