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N Engl J Med 380(24):22952306 Kristensen SL, Rrth R, Jhund PS, Docherty KF, Sattar N, Preiss D et al (2019) Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
Slowing Gastric Emptying By slowing the stomachs emptying process, these medications promote a feeling of fullness
doses of other antidiabetic drugs may need adjustment
Primary concerns include additive cardiovascular effects (tachycardia, hypertension), intensified gastrointestinal symptoms (nausea, vomiting, constipation), central nervous system effects (insomnia, anxiety), and excessive appetite suppression potentially leading to nutritional deficiencies
They do this by lowering oxidative stress on hair follicles
Additionally, ACSL4 and Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) are key lipid drivers of ferroptosis
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