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Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders

While the molecular ruthenium catalyst and the nanoreactors without carbon fluorinated moieties were cytotoxic in the low micromolar range in a 21% O 2 atmosphere, these compounds lost their therapeutic effect in a 1% O 2 atmosphere

Martins et al., 2018)

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Clinical outcomes in patients are presenting with a systemic oxidative burden, which results in persistent fatigue, delayed recovery from physical exertion, and early dermatological signs of premature aging