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The FDA page on substances that may present significant safety risks notes potential concern around congestive heart failure for ibutamoren, citing a trial stopped early due to a possible CHF safety signal

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Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jdar E, Leiter LA, Lingvay I, Rosenstock J, Seufert J, Warren ML

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Their baseline impairment was measured and then they consumed alcohol

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While mediation analyses suggest that improved glycemic control, weight loss, and reduced blood pressure contribute to these benefits, they likely do not fully explain the observed renoprotection [36,37,38]

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