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The Dysesthesia Safety Signal The most-discussed Phase 3 finding has been dysesthesia abnormal skin sensations including tingling, burning, or pricking reported at 20.9% incidence at the 12 mg dose versus 0.7% on placebo in TRIUMPH-4

Its ability to target multiple pathways makes it one of the most effective options in the GLP-1 weight loss category today

Pancreatitis A 2023 systematic review across five databases analyzed rates of adverse events associated with tirzepatide

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M., Vercruysse, F., & Fitchet, M

GLP-1 exerts its anorectic effect in part by acting on the hunger-satiety centre located in the arcuate nucleus of the hypothalamus, and in part by delaying gastric emptying