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Funding This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants R01 DK102142 (Hartmut Jaeschke) and R01 DK125465 (Anup Ramachandran), and by the National Institute of General Medical Sciences (NIGMS)-funded Liver Disease COBRE grants P20 GM103549 (Hartmut Jaeschke) and P30 GM118247 (Hartmut Jaeschke)

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However, environmental factors are required for the development of manifest disease

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