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These findings align with our plasma biomarker analyses demonstrating reduced plasma levels of the cytokines tumour necrosis factor and MCP-1 in CNS GIPR KO mice, as well as existing literature showing that GLP-1R agonists targeted to CNS GLP-1R have anti-inflammatory effects 20

For many of our patients, the cost of our program is significantly less than paying for a brand-name drug out-of-pocket

That framing matters enormously for insurance coverage, for public health budgets, and for whether the people who need them most will ever actually have access to them

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Exenatide: Available in both twice-daily and weekly injection forms, Exenatide is one of the earlier medications in this category