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We present an overview of these findings

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She has a particular interest in reproductive, sexual, and womens health

The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

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As weight decreases and insulin resistance improves, the hormonal environment becomes more stable, potentially restoring normal ovarian function