A 2026 meta-analysis in eClinicalMedicine found patients regain about 60% of lost weight within a year of stopping
However, these same trials documented various side effects that occur during the initial dose-escalation phase, including gastrointestinal symptoms and fatigue in a portion of participants
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The Dual Challenge: Obesity and Sarcopenia in Older Age Age-related changes in body composition are characterized by decreased fat-free mass (FFM), which includes reductions in total muscle mass and bone mineral density (BMD), alongside a relative increase in fat mass (FM) [13]