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GSH exists mainly in the reduced form which protects cells from oxidative damage by donating electrons to neutralize ROS and other free radicals (61)

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Anti-ageing conditions including insulin resistance, diabetes, cancer, and arthritis may be defended against by glutathione

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Plant polyphenols, such as resveratrol found in grapes and red wine, can activate key regulatory pathways involving sirtuins and the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), which promote the expression of genes involved in mitochondrial function 15,16,17