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Lipohyalinosis, involving deposition of lipid and hyaline material within vessel walls, further compromises vascular integrity

At standard doses, most of the medication remains localized to vaginal tissue and produces minimal systemic hormone exposure

Resolution of a renal sulfhydryl (glutathione) oxidase from gamma-glutamyltransferase

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It has been reported to cause vomiting, diarrhea, a fishy body odor, abdominal cramps, and nausea

Common side effects like nausea and constipation occur at similar rates regardless of compounding source, because they relate to the drug mechanism, not manufacturing location