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A 2025 meta-analysis found tirzepatide (the drug in Mounjaro and Zepbound) lowered inflammation markers hsCRP by about 33% and IL-6 by about 18% versus placebo

Reasons for exclusion at the full-text stage were recorded and reported in accordance with the PRISMA-ScR flow diagram (Supplementary Fig

While current therapies are often effective during initiation, they tend to lose efficacy as time passes and only provide symptom control without addressing the underlying progressive nature of the disease

In contrast to the control tumor MET low-expression mouse model, the mouse model with heightened MET expression exhibited lower effective treatment response to the anti-PD-1 antibody, leading to ongoing tumor growth

The gap between the two is where most of the confusion lives

Prasad and Ramakant, 2025)