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Elevated post-meal insulin directly inhibits the lipolytic pathway that AOD-9604 activates
The 2 mL volume produces concentrations (2.5, 5, 10, 15 mg/mL) that put common doses on multiples of 10 units
Even with normal absorption efficiency, low intake creates deficiency risk
The FDA acknowledges BII and has worked to increase awareness
Do note that this number varies for every individual depending on the skin and pigmentation, and its severity
Patients with diagnosed diabetes should monitor glucose closely, as MOTS-cs insulin-sensitizing effects may potentiate hypoglycemia when combined with antidiabetic medications
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