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Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

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SIRT3, found in mitochondria, needs NAD+ to work

The resulting mitochondrial stress activates key innate immune pathways, including cGAS-STING, TLR9, and NLRP3 inflammasome signaling, which collectively determine the balance between protective immunity and immunopathology (Xian et al., 2022)

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