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A rare few people seem to have an intolerance of B12, otherwise the main problem when having b12 injections initially is acne-type spots affecting face, hairline, scalp, neck usually

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Most people require 3 to 6 microneedling sessions, spaced about 4 to 6 weeks apart, for optimal results

Topical applications may show initial improvements in skin texture and hydration within 2-4 weeks, with more significant changes in collagen production and skin firmness becoming apparent after 8-12 weeks of consistent use