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Semaglutide does have several potentially serious side effects

10.1016/j.bbr.2009.06.035 2 AbbottC

Calcidiol is the major form of vitamin D found in the circulation and is transported in the blood bound to the vitamin D-binding protein encoded by the GC gene

Payers and clinicians will be looking for event-based value, not just blood pressure reduction

In the SURMOUNT5 trial, participants lost an average of 20.2 % of their baseline body weight over 72 weeks with tirzepatide, with a greater proportion achieving weight-loss thresholds of 1525 % compared with semaglutide

increasing attention is being paid to risks related to lean mass loss, neuropsychiatric effects, and long-term organ safety (Table 3)